Bioprocess Associate 2 – Downstream

Aruna Bio | Manufacturing / Bioprocessing

Aruna Bio is a clinical-stage biotech company advancing a new class of cell-free biologics — exosomes — for the treatment of central nervous system and neurodegenerative disorders. We're looking for a

Bioprocess Associate 2 – Downstream to join our manufacturing team and support production of AB126, our lead therapeutic exosome candidate.

As a Downstream Bioprocess Associate 2, you'll be executing established bioprocess workflows and purifications in a cGMP environment, as well as contributing to the planning and procurement for future productions/purifications. We need someone with solid hands-on lab skills, disciplined documentation habits, and the ability to work both independently and in a group, within defined protocols.

Core Responsibilities

• Perform downstream bioprocess workflows, including TFF systems, chromatography, and fill-finish, per established protocols and cGMP standards
• Support and occasionally participate in upstream bioprocess workflows via basic supply preparations, formulations, and documentation for mammalian cell culture
• Operate production equipment (pipettors, balances, biosafety cabinets, incubators, autoclaves, microscopes, centrifuges) accurately and safely
• Complete manual, cGDP-compliant documentation in batch records and forms with a high degree of accuracy
• Coordinate downstream supply needs (e.g. equipment and consumables sourcing/pricing) and assist with planning for future purifications
• Analyze downstream performance and production data and help generate reports.
• Collaborate with Process Development Team on technical transfer and experiment needs
• Contribute to the editing/updating of controlled process documentation as needed
• Mentor, train, and review the work and documentation of junior team members as needed

Required Skills and Experience

• Bachelor's degree in a relevant field (e.g. bioprocessing, chemistry, biology) with 3+ years of directly relevant experience; or a master's degree with 1+ years of relevant experience; or an associate degree with a minimum of 5 years of relevant experience
• Previous professional experience with pilot or production-scale TFF purification and/or chromatography
• Excellent organizational and communication skills, and the ability to manage substantial technical data, multiple priorities, and competing deadlines
• Strong attention to detail and document review skills to reliably produce audit-ready process documentation
• Proficiency with primary Microsoft Office Suite tools (Outlook, Microsoft Word, PowerPoint, Excel)
• Ability to work cooperatively in a controlled environment (ISO 5, 7, and 8) wearing clean room PPE for extended periods of time
• Willingness to participate in a rotating weekend work and holiday schedule to perform primary cell culture maintenance processes

Preferred

• Hands-on industrial experience in a cGMP-compliant environment
• Previous experience leading and operating commercial-scale FPLC, TFF, and other purification technologies
• Proficiency with statistical analysis tools (e.g. JMP, Prism)
• Working knowledge of downstream production principles specific to cell-free biologics

To apply: Send a cover letter and resume to Sign in to view email with the subject line "Bioprocess Associate 2 – Downstream."

Aruna Bio is an equal opportunity employer.